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Acomplia (Rimonabant) and Weight Loss

Rimonabant, a new weight loss drug marketed under the name Acomplia, by Sanofi Aventis, has recently been approved by the EU. Clinical trials have found that Rimonabant can help overweight and obese people to lose weight. It was also found that the drug could reduce the risk of cardiovascular heart disease and diabetes, and be of help to people who are trying to stop smoking.

Rimonabant targets an area in the brain called the Endocannabinoid System. It blocks the receptors in this area, meaning that Cannabinoids (chemical compounds containing ‘hungry’ messages) cannot reach the system. This lowers the intake of food, resulting in weight loss.

The Endocannabinoid system affects the regulation of energy use, the breaking down of sugars, lipids and of the regulation of body weight and metabolism.

Rimonabant targets visceral fat, a layer of fat which forms around internal organs. Reducing this layer of fat has been found to stem the production of harmful substances (such as cholesterol), which prevent the body responding to insulin. This effectively means that Rimonabant can lower the risk of diabetes and cardiovascular heart disease.

In the study, more than 1,500 obese people were given a calorie-controlled diet, together with either 5mg or 20mg of rimonabant each day or a dummy drug. After one year, two thirds of the participants taking the largest dose had lost at least 5 percent of their weight. Better still, of these, 39 percent lost more than 10 percent. Meanwhile, patients on the 20mg dose lost on average, 4cm from their waist and risk factors for heart disease including raised cholesterol, insulin resistance and the presence of metabolic syndrome improved.

External Links:

Rimonabant Could be 'Miracle' Weight Loss Pill: NPR's Patricia Neighmond reports on a new "miracle pill" that helps obese people lose weight and keep it off.

Rimonabant produces sustained weight loss long term: Use of the weight-loss medication rimonabant produced modest yet sustained weight loss after 2 years, and improved HDL cholesterol and triglyceride levels, according to a study in the February 15 issue of JAMA: The Journal of the American Medical Association.